Corynebacterium diphtheriae group – New validation reports available
Corynebacteria, which are important pathogen agents for humans and animals, are summarized in the Corynebacterium (C.) diphtheriae group. This group includes in particular C. diphtheriae (pathogen of classical diphtheria), C. belfantii, C. ulcerans and C. pseudotuberculosis. Since 2020, further species have been described within the group: C. ramonii, C. rouxii, and C. silvaticum. These species are closely related to each other, making reliable species identification difficult. To date, these important new pathogens have not been integrated in common commercial databases. User made MSPs of all members of the C. diphtheriae group are available for exchange in the MALDI-UP catalog now.
Using these new reference entries, the species identification of the C. diphtheriae group in the Bruker Biotyper system can be improved. As evidence, four formal validations from the CVUA Stuttgart for C. diphtheriae, C. ulcerans+ramonii, C. pseudotuberculosis and C. silvaticum are now presented in the tools-section of the MALDI-TOF MS User Platform.
Targets: members of the C. diphtheriae group:
- C. diphtheriae
- C. ulcerans+ramonii
- C. pseudotuberculosis
- C. silvaticum
Validation for the BRUKER Biotyper database version K, extended by 1826 msp from the MALDI-UP catalogue.
Fully functional Excel reports in German.
Criteria based on the guidelines for MALDI validation in a single laboratory (BVL, 2022).
The work was carried out in support of the Corynebacterium pseudotuberculosis consiliary laboratory (DVG) at the CVUA Stuttgart.
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